Welcome to the Han Lab

Mechanisms of Skeletal and Cardiac Muscle Diseases

The research projects in the Han Lab are aimed at elucidating the molecular mechanisms of genetic diseases of skeletal and cardiac muscle such as muscular dystrophy and cardiomyopathy. By understanding the molecular mechanisms of these genetic disorders, we hope to shed light on the design of novel therapeutic strategies for these devastating diseases.

DGC

Sample Completed Projects

MCOLN1 is required for sarcolemma repair   Read more

Mitochondrial cardiolipin is required for NLRP3 inflammasome activation   Read more

Myostatin gene editing   Read more

TRPM2 links oxidative stress to NLRP3 inflammasome activation   Read more

Dysferlin forms a dimer in vitro and in vivo   Read more

Complement ablation ameliorates disease progression in dysferlin-null mice   Read more

Protective mechanism of alpha-dystroglycan for the sarcolemma integrity   Read more

The role of dysferlin-mediated membrane repair in the heart   Read more